Product Identification

Product Name

Chloromycetin

Synonyms

2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide
Amphenicol
Amseclor
Chlomycol
D-Chloramphenicol
D-Threo-Chloramphenicol

CAS

56-75-7

Formula

C11H12Cl2N2O5

Molecular Weight

323.13

EINECS

200-287-4

RTECS

AB6825000

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Natural Product

Merck

13,2087

Beilstein/Gmelin

2225532

Beilstein Reference

4-13-00-02742

Physical and Chemical Properties

Appearance

Pale yellow plates or needles from water. White/gray/yellow powder.

Solubility in water

2.5 g/L (25 C)

Melting Point

150

Boiling Point

645

Vapor Pressure

2E-17 (25 C)

Density

1.49 g/cm3

pKa/pKb

11.03 (pKa)

Partition Coefficient

1.02

Heat Of Vaporization

100.0 kJ/mol

Usage

Medication.

Vapor Density

11.1

Refractive Index

1.5403 (164 C)

First Aid Measures

Ingestion

Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. If irritation develops, get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container. Store protected from light.

Handling

Wash hands before eating. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Store protected from light.

Hazards Identification

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver damage. May cause hemorrhaging of the digestive tract. Exposure may cause anemia and other blood abnormalities.

EC Risk Phrase

R 40

EC Safety Phrase

S 22 36/37

UN (DOT)

1851

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

May cause cancer in humans.

Fire Fighting Measures

Flash Point

344

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Acids, acid chlorides, acid anhydrides and oxidizing agents.

Stability

Stable under normal shipping and handling conditions.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Transport Information

UN Number

1851