Product Identification

Product Name

Alfacalcidol

Synonyms

1a-Hydroxyvitamin D3
1-Hydroxycholecalciferol
9,10-Secocholesta-5,7,10(19)-triene-1,3-diol, (1a,3b,5Z,7E)-

CAS

41294-56-8

Formula

C27H44O2

Molecular Weight

400.65

EINECS

255-297-1

RTECS

VS2851000

RTECS Class

Drug; Reproductive Effector

Merck

12,4864

Beilstein/Gmelin

1916848

Beilstein Reference

5-06

Physical and Chemical Properties

Appearance

Fine white crystals

Solubility in water

Insoluble

Melting Point

132 - 133

Vapor Pressure

2E-13 (25 C)

pKa/pKb

13.82 (pKa)

Heat Of Vaporization

92.83 kJ/mol

Usage

A form of vitamin d. It is converted rapidly in the liver to the active metabolite, 1,25-dihydroxycholecalciferol (calcitriol).

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician immediately.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed. Store at -20 C

Hazards Identification

Inhalation

May be fatal if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be fatal if absorbed through skin.

Eyes

May cause eye irritation.

Ingestion

May be fatal if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

26/27/28

EC Safety Phrase

28 36/37 45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves.

Respirators

Government approved respirator.

Exposure Effects

Very toxic by inhalation, in contact with skin and if swallowed.

Fire Fighting Measures

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I