Product Identification

Product Name

Ethyl (3alpha,16alpha)-eburnamenine-14-carboxylate

Synonyms

(3a, 16a)-Eburnamenine-14-carboxylic acid ethyl ester
Cavinton
Eburnamenine-14-carboxylic acid ethyl ester
Ethyl apovincaminate

CAS

42971-09-5

Formula

C22H26N2O2

Molecular Weight

350.46

EINECS

256-028-0

RTECS

JW4792000

RTECS Class

Drug; Reproductive Effector

Merck

12,10128

Beilstein/Gmelin

900803

Beilstein Reference

6-25

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Insoluble

Melting Point

147 - 153

Boiling Point

480

Vapor Pressure

2E-9 (25 C)

Density

1.27 g/cm3

pKa/pKb

5.95 (pKb)

Heat Of Vaporization

74.5 kJ/mol

Usage

Ca - calmodulin-dependent phosphodiesterase i (pde1) inhibitor.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed.

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

22

EC Safety Phrase

36

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Harmful. Harmful if swallowed. Target organ(s): Brain.

Fire Fighting Measures

Flash Point

244

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.