Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Pseudoephedrine(90-82-4)

Product Identification Physical and Chemical Properties First Aid Measures Handling and Storage Hazards Identification Exposure Controls/Personal Protection Fire Fighting Measures Accidental Release Measures Stability and Reactivity
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Product Identification

Product Name

Pseudoephedrine

Synonyms

D-Isoephedrine
D-psi-Ephedrine
Isoephedrine
psi-Ephedrin
Psi-Ephedrine
trans-Ephedrine

CAS

90-82-4

Formula

C10H15NO

Molecular Weight

165.26

EINECS

202-018-6

RTECS

UL5800000

RTECS Class

Drug; Human Data

Beilstein/Gmelin

2414132

Beilstein Reference

4-13-00-01878

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Physical and Chemical Properties

Appearance

Rhombic tablets from ether.

Solubility in water

Very soluble

Melting Point

58 - 59

Boiling Point

255

Vapor Pressure

0.009 (25 C)

Density

1.118 g/cm3

pKa/pKb

4.62 (pKb)

Partition Coefficient

1.05

Heat Of Vaporization

52.0 kJ/mol

Usage

Medication.

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First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

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Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

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Hazards Identification

Skin

Fixed drug eruptions, pseudo-scarlatina and systemic contact dermatitis have been reported.

Ingestion

Anorexia, nausea, and vomiting are common. Ischemic colitis has been associated with therapeutic pseudoephedrine administration.

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Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Not available.

Exposure Effects

Elevated blood pressure may occur, usually accompanied by rapid heart rate. Reduced body temperature and abnormally low blood pressure were reported in a case of a mixed drug overdose. anxiety, nervousness, insomnia, muscle tremor, seizures, and altered mental status may be noted. Drowsiness has been seen after overdose in children. Intracerebral hemorrhage has occurred. Hallucinations may occur, particularly in children. Coma has occurred in a mixed drug overdose. Pseudoephedrine is US FDA Pregnancy Category C. It is excreted in breast milk in low amounts.

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Fire Fighting Measures

Flash Point

89

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

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Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

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Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.