Product Identification

Product Name

3-Hydroxy-1-nitrobenzene

Synonyms

1-Hydroxy-3-nitrobenzene
3-Nitrophenol

CAS

554-84-7

Formula

C6H5NO3

Molecular Weight

139.11000000000001

EINECS

209-073-5

RTECS

SM1925000

RTECS Class

Mutagen; Primary Irritant

Merck

12,6716

Beilstein/Gmelin

1907946

Beilstein Reference

4-06-00-01269

EC Class

harmful, irritant

Physical and Chemical Properties

Appearance

Colorless to pale yellow crystalline solid.

Solubility in water

30 g/L

Melting Point

94 - 95

Boiling Point

271

Vapor Pressure

0.004 (25 C)

Density

1.485 g/cm3 (20 C)

pKa/pKb

8.33 (pKa)

Partition Coefficient

2

Heat Of Vaporization

53.0 kJ/mol

Heat Of Combustion

-2875 kJ/mol

Usage

As indicator in 0.3% Soln in 50% alcohol ph: 6.8 Colorless, 8.6 Yellow.

Vapor Density

4.8

Odor threshold

3.0 mg/m3

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid immediately. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Remove contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Do not ingest or inhale. Wash clothing before reuse. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.

Hazards Identification

Inhalation

May cause respiratory tract irritation. May cause effects similar to those described for ingestion. May cause drowsiness, unconsciousness, and central nervous system depression.

Skin

Causes skin irritation. May be absorbed through the skin in harmful amounts. If absorbed, may cause symptoms similar to those for ingestion.

Eyes

Causes severe eye irritation.

Ingestion

Harmful if swallowed. May cause irritation of the digestive tract. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. May cause methemoglobinemia, cyanosis, convulsions, and death. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 20/21/22 33 36/37/38 43

EC Safety Phrase

S 26 36/37/39

UN (DOT)

1663

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Abnormally low blood pressure, reduced body temperature, rapid breathing, and rapid heart rate may develop with severe toxicity. Initial CNS excitation, including seizures, is commonly followed by CNS depression ranging from lethargy to coma and death. Fetotoxicity and skeletal abnormalities have been reported in animal experiments.

Poison Class

2

Fire Fighting Measures

Flash Point

101.7

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Fire Potential

Nitrophenol is combustible though it may take some effort to ignite. Nitrophenol aromatic nitrocompounds are flammable.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Remove all sources of ignition. Provide ventilation.

Stability and Reactivity

Disposal Code

3

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents; Strong bases.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Combustion Products

Dangerous toxic fumes of NO x

Transport Information

UN Number

1663

Hazard Class

6.1

Packing Group

III

HS Code

2908 90 00