Product Identification

Product Name

Sulindac

Synonyms

(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-[(p-methylsulfinyl)benzylidenyl]indene-3-acetic acid

CAS

38194-50-2

Formula

C20H17FO3S

Molecular Weight

356.42

EINECS

253-819-2

RTECS

NK8226000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,9155

Beilstein/Gmelin

2951842

Beilstein Reference

6-10

Physical and Chemical Properties

Solubility in water

Insoluble

Melting Point

195

Boiling Point

582

Vapor Pressure

2E-14 (25 C)

pKa/pKb

4.22 (pKa)

Partition Coefficient

3.42

Heat Of Vaporization

91.5 kJ/mol

Usage

Nonsteroidal anti-inflammatory; preferential inhibitor of cox-1.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed.

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

22

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Toxic if swallowed. Target organ(s): Liver. G.I. System.

Fire Fighting Measures

Flash Point

306

Fire Fighting

Extinguish using Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Sulfur oxides, Hydrogen fluoride.