Product Identification

Product Name

sigma-Picoline

Synonyms

4-Picoline
p-Picoline

CAS

108-89-4

Formula

C6H7N

Molecular Weight

93.13

EINECS

203-626-4

RTECS

UT5425000

RTECS Class

Primary Irritant

Merck

12,7556

Beilstein/Gmelin

104586

Beilstein Reference

5-20-05-00543

EC Index Number

613-037-00-8

EC Class

Flammable; Toxic; Harmful; Irritant

Physical and Chemical Properties

Appearance

Colorless moderately volatile liquid.

Solubility in water

Soluble

Melting Point

3

Boiling Point

144.9

Vapor Pressure

6.5 (25 C)

Density

0.9547 g/cm3 (20 C)

pKa/pKb

6.04 (pKb)

Partition Coefficient

1.22

Heat Of Vaporization

44.9 kJ/mol

Heat Of Combustion

-3421 kJ/mol

Usage

Manufacture of isonicotinic acid and derivatives, in water-proofing agents for fabrics, as solvent for resins.

Vapor Density

3.2

Refractive Index

1.5064 (20 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Skin

Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Store protected from moisture.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.

Hazards Identification

Inhalation

Causes irritation of mucous membrane. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. Exposure may give rise to flushing of face, skin rash, an increase in heart and respiration rates, headaches, giddiness, nausea, and vomiting. May cause burning sensation in the chest.

Skin

Causes skin irritation. Harmful if absorbed through the skin. May cause reddening of the skin. May cause skin rash and eruptions. Substance is readily absorbed through the slkin. May cause cyanosis of the extremities.

Eyes

Causes eye irritation. May cause chemical conjunctivitis and corneal damage.

Ingestion

May cause irritation of the digestive tract. Ingestion of large amounts may cause CNS depression. Intoxication may include weight loss, diarrhea, weakness, ataxia, and unconsciousness.

Hazards

Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers.

EC Risk Phrase

R 10 20/22 24 36/37/38

EC Safety Phrase

S 26 36 45

UN (DOT)

2313

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

May cause liver and kidney damage. Effects may be delayed.

Exposure limit(s)

PDK (as mixture of isomers): 5 mg/m3 (USSR 1991).

Poison Class

4

Fire Fighting Measures

Flash Point

50

Autoignition

> 500

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing media: Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT get water inside containers. Do NOT use straight streams of water. For large fires, use water spray, fog or regular foam. For small fires, use dry chemical, carbon dioxide, water spray or regular foam.

Upper exp. limit

8.7

Lower exp. limit

1.3

Fire Potential

Moderate fire risk

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container. Avoid runoff into storm sewers and ditches which lead to waterways. Remove all sources of ignition. Use a spark-proof tool. Do not get water inside containers. A vapor suppressing foam may be used to reduce vapors.

Stability and Reactivity

Disposal Code

9

Incompatibilities

Moisture, water, oxidizing agents.

Stability

Stable under normal temperatures and pressures. Hygroscopic: absorbs moisture or water from the air.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Combustion Products

Fire will produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2313

Hazard Class

3

Packing Group

III

HS Code

2933 39 55