Product Identification

Product Name

3-Chloropropiononitrile

Synonyms

3-Chloropropionitrile
beta-Chloropropionitrile

CAS

542-76-7

Formula

C3H4ClN

Molecular Weight

89.53

EINECS

208-827-0

RTECS

UG1400000

RTECS Class

Other

Merck

13,2179

Beilstein/Gmelin

1098454

Beilstein Reference

4-02-00-00751

EC Class

very toxic, irritant

Physical and Chemical Properties

Appearance

Colorless liquid with a characteristic acrid odor.

Solubility in water

45 g/L

Melting Point

-52

Boiling Point

175

Vapor Pressure

1.1 (25 C)

Density

1.1443 g/cm3 (18 C)

Partition Coefficient

.18

Heat Of Vaporization

41.3 kJ/mol

Usage

In pharmaceutical & polymer synthesis, combines the reactivity of nitrile & an alkyl halide.

Vapor Density

3

Refractive Index

1.4322 (20 C)

First Aid Measures

Ingestion

Do not induce emesis. Activated charcoal: administer charcoal as a slurry (240 ml water/30 g charcoal). Usual dose: 25 to 100 g in adults/adolescents.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Tachypnea, dyspnea, and hyperpnea may occur early. Hypoventilation leading to apnea and cyanosis may be seen late in the course. Noncardiogenic pulmonary edema may develop.

Eyes

Eye irritation may be seen. Dilated pupils and equally red retinal arteries and veins may be seen.

Ingestion

Nausea and vomiting may occur.

Hazards

Toxic gas (hydrogen chloride) is released when the compound is heated above 266F. When heated to decomposition, it emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat.

EC Risk Phrase

R 26/27/28

EC Safety Phrase

S 23 28 36/37/39 45

UN (DOT)

3276

Exposure Controls/Personal Protection

Personal Protection

Wear appropriate equipment to prevent: any possibility of skin contact. Wear eye protection to prevent: any possibility of eye contact. The following equipment should be available: eyewash, quick drench. Cyanides

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Exposure Effects

Hyperpnea, rapid breathing, hypoventilation and apnea occur with cyanide poisoning. Rapid heart rate and elevated blood pressure, followed by low heart rate and abnormally low blood pressure are also signs of cyanide poisoning. Agitation, headache, anxiety, coma, and convulsions may be seen. No reproductive studies were found for 3-chloropropionitrile. Related nitrile compounds have been teratogenic in experimental animals.

Fire Fighting Measures

Flash Point

76

Fire Fighting

(Non-Specific -- Propionitrile) Wear positive pressure breathing apparatus and special protective clothing. Isolate for 1/2 mile in all directions if tank car or truck is involved in fire.Alcohol foam is recommended, but water spray can be used because the material can be cooled below its flash point.

Fire Potential

Moderately flammable. Has been assigned an NFPA flammability hazard ranking of 2.

Accidental Release Measures

Small spills/leaks

(Non-Specific -- Propionitrile) Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Absorb small spills with sand or other noncombustible absorbent material. Dike far ahead of spill for later disposal. Isolate hazard area and deny entry. Stay upwind.

Stability and Reactivity

Disposal Code

9

Stability

Normally stable. May become unstable at elevated temperatures and/or pressures.

Decomposition

Begins to decomposition when heated above 130 C evolving hydrogen chloride.

Transport Information

UN Number

3276

HS Code

2926 90 95