Product Identification

Product Name

Propofol

Synonyms

2,6-Bis(1-methylethyl)phenol
2,6-Bis(isopropyl)phenol
2,6-Diisopropylphenol
Diprofol
Disoprivan
Recofol

CAS

2078-54-8

Formula

C12H18O

Molecular Weight

178.27

EINECS

218-206-6

RTECS

SL0810000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,8020

Beilstein/Gmelin

1866484

Beilstein Reference

4-06-00-03435

Physical and Chemical Properties

Appearance

Yellow-tan liquid.

Solubility in water

Insoluble

Melting Point

18

Boiling Point

256

Vapor Pressure

0.01 (25 C)

Density

1.032 g/cm3

pKa/pKb

11.00 (pKa)

Partition Coefficient

4.16

Heat Of Vaporization

51.3 kJ/mol

Usage

An intravenous sedative-hypnotic agent.

Refractive Index

1.5134 (20 C)

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container. Keep under an argon blanket. Refrigerator (approx 4 C).

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Use only in a chemical fume hood.

Hazards Identification

Ingestion

Harmful if swallowed. May cause irritation of the digestive tract.

Inhalation

Dust is irritating to the respiratory tract. The toxicological properties of this substance have not been fully investigated.

Skin

Causes skin irritation.

Eyes

Causes eye irritation.

EC Risk Phrase

R 22 36/38

EC Safety Phrase

S 26 36/37/39

UN (DOT)

2810

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point

107

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures

Small spills/leaks

Absorb spill with inert material, (e.g., dry sand or earth), then place into a chemical waste container.

Stability and Reactivity

Incompatibilities

Oxidizing agents, bases, acid chlorides, acid anhydrides.

Stability

Stable under normal temperatures and pressures.

Decomposition

Carbon monoxide, carbon dioxide.

Transport Information

UN Number

2810