Product Identification

Product Name

1-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide

Synonyms

3-(2-(Dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide
GR-43175
GR-43175X
Imigran
Imitrex

CAS

103628-46-2

Formula

C14H21N3O2S

Molecular Weight

295.41000000000003

RTECS

NL9482200

Merck

12,9172

Beilstein/Gmelin

6930870

Physical and Chemical Properties

Appearance

Distributed as a 5 - 20% aqueous solution.

Solubility in water

Soluble

Melting Point

169 - 171

Boiling Point

498

Vapor Pressure

4.8E-10 (25 C)

Density

1.243 g/cm3 (20 C)

pKa/pKb

11.31 (pKa)

Partition Coefficient

-2.3

Heat Of Vaporization

76.6 kJ/mol

Usage

A triptan drug including a sulfonamide group.

First Aid Measures

Ingestion

Never attempt to induce vomiting. Do not attempt to give any solid or liquid by mouth if the exposed subject is unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty of water to drink. Obtain medical attention.

Inhalation

Physical form suggests that risk of inhalation exposure is negligible.

Skin

Using appropriate personal protective equipment, remove contaminated clothing and flush exposed area with large amounts of water. Obtain medical attention if skin reaction occurs, which may be immediate or delayed.

Eyes

Wash immediately with clean and gently flowing water. Continue for at least 15 minutes. Obtain medical attention.

Handling and Storage

Storage

No storage requirements necessary for occupational hazards. Follow product information storage instructions to maintain efficacy.

Exposure Controls/Personal Protection

Personal Protection

Protective gloves and clothing. Chemical safety goggles.

Exposure Effects

Medical treatment in cases of overexposure should be treated as an overdose of a 5-hydroxytryptamine agonist. Treat according to locally accepted protocols. For additional guidance, refer to the current prescribing information or to the local poison control information centre.

Fire Fighting Measures

Fire Fighting

For single units (packages): No special requirements needed. For larger amounts (multiple packages/pallets) of product: Since toxic, corrosive or flammable vapors might be evolved from fires involving this product and associated packaging, self contained breathing apparatus and full protective equipment are recommended for firefighters. If possible, contain and collect firefighting water for later disposal.

Fire Potential

Product is non combustable.

Accidental Release Measures

Small spills/leaks

Collect and place it in a suitable, properly labeled container for recovery or disposal.