Product Identification

Product Name

N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide

Synonyms

4-((2-Methylhydrazino)methyl)-n-Isopropylbenzamide
Ibenzmethyzin
n-(1-Methylethyl)-4
n-4-isopropylcarbamoylbenzyl-n'-methylhydrazine
n-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide
p-(N'-Methylhydrazinomethyl)-n-Isopropylbenzamide

CAS

671-16-9

Formula

C12H19N3O

Molecular Weight

221.3

EINECS

211-582-2

RTECS

XS4550000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector

Merck

12,7938

Beilstein/Gmelin

958270

Physical and Chemical Properties

pKa/pKb

6.6 (pKa)

Partition Coefficient

.06

Usage

Medication (vet).

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Interstitial pneumonitis occurs rarely and may be an allergic reaction during therapeutic use.

Skin

Pruritus, hyperpigmentation, flushing, alopecia, and jaundice may be noted. Herpetic lesions may occur.

Eyes

Nystagmus, diplopia, papilledema, photophobia and retinal hemorrhage may occur with therapeutic use.

Ingestion

Ausea, vomiting and diarrhea may occur.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Respiratory protection should be an adjunct to and not a substitute for engineering controls.<BR>Organic vapor acid gas canister; done in the open, an area away from drafts and traffic

Exposure Effects

Procarbazine is a weak mao inhibitor. A hypertensive reaction may occur with concurrent use of sympathomimetic agents, tricyclic antidepressants, and foods with high tyramine content; these reactions are poorly documented. with therapeutic use - paresthesias, neuropathies, dizziness, headache, insomnia, frequent nightmares, nervousness, depression, hallucinations, seizures, coma and tremors have been reported. Procarbazine is not recommended for use during pregnancy or lactation.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Evacuate area and ventilate. Wear protective equipment. If required, use an inert absrobent. Sweep up and place in an appropriate container for disposal. Wash contaminated surfaces.

Stability and Reactivity

Stability

Stable in light, slowly oxidized in air. Hydrochloride stable @ room temperature (in presence of oxygen, oxidn is accelerated by incr temperature).

Incompatibilities

Strong oxidizing agents.