Product Identification

Product Name

9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide

Synonyms

2-Amino-5-methylbenzoic acid
2-Carboxy-4-methylaniline
5-Methyl-2-aminobenzoic acid
5-Methylanthranilic acid
9a-Fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide
9-a-fluoro-11-b,21-dihydroxy-16-a,17-a-isopropylidenedioxypregna-1,4-diene-3,20-dione
9a-Fluoro-16a,17a-isopropylidenedihydroxyprednisolone
9a-Fluoro-16a-hydroxyprednisolone 16a,17a-acetonide
Kenalog
Polcortoon

CAS

2941-78-8

CAS

76-25-5

Formula

C24H31FO6

Formula

C8H9NO2

Molecular Weight

434.5

Molecular Weight

151.16

EINECS

200-948-7

EINECS

220-932-3

RTECS

TU3920000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,9728

Beilstein/Gmelin

1101527

Beilstein/Gmelin

60069

Beilstein Reference

5-19-06-00568

Beilstein Reference

4-14-00-01357

Physical and Chemical Properties

Appearance

Beige - light brown powder.

Solubility in water

Insoluble

Solubility in water

Very soluble

Melting Point

274

Boiling Point

317

Boiling Point

577

Vapor Pressure

0.0002 (25 C)

Vapor Pressure

1E-15 (25 C)

pKa/pKb

2.08 (pKa)

pKa/pKb

12.69 (pKs)

Partition Coefficient

1.67

Heat Of Vaporization

58.9 kJ/mol

Heat Of Vaporization

99.2 kJ/mol

Usage

A synthetic corticosteroid. Used for replacement therapy in people whose adrenal glands are not producing enough natural steroids (adrenal insufficiency) and decreasing inflammation in certain disease states. .

Usage

Metabolic antagonist.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Inhalation

Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Causes skin irritation.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Eyes

Causes eye irritation.

Handling and Storage

Storage

Keep tightly closed.

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Ingestion

May be harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

R 36/37/38

EC Safety Phrase

S 26 36

EC Safety Phrase

22 24/25

Exposure Controls/Personal Protection

Personal Protection

Protective gloves. Chemical safety goggles.

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Wear dust mask.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Avoid contact and inhalation. Target organ(s): Endocrine system.

Fire Fighting Measures

Flash Point

145

Flash Point

303

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

No data.

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Hydrogen fluoride.

Decomposition

Carbon monoxide, oxides of nitrogen, carbon dioxide.