Product Identification

Product Name

2-Chloro-2'-deoxyadenosine

Synonyms

2-CdA
2-Chloro-2'-deoxyadenosine
2-Chloro-6-amino-9-(2-deoxy-b-D-erythro-pentofuranosyl)purine
2-Chlorodeoxyadenosine
Cladribine
Leustatin

CAS

4291-63-8

Formula

C10H12ClN5O3

Molecular Weight

285.69

RTECS

AU7357560

Merck

12,2397

Beilstein/Gmelin

624220

Physical and Chemical Properties

Appearance

White solid.

Solubility in water

Insoluble

Melting Point

220

Vapor Pressure

4.0E-15 (25 C)

Density

2.03 g/cm3 (20 C)

pKa/pKb

12.41 (pKb)

Partition Coefficient

.02

Usage

A drug commonly used to treat hairy cell leukemia.

First Aid Measures

Ingestion

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.

Inhalation

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.

Skin

In case of contact, immediately flush skin with plenty of water. Cover the irritated skin with an emollient. Remove contaminated clothing and shoes. Wash clothing before reuse. Thoroughly clean shoes before reuse. Get medical attention.

Eyes

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention.

Handling and Storage

Storage

Keep container tightly closed, in a cool, well-ventilated area. Do not store above 4 C.

Hazards Identification

Skin

Hazardous in case of skin contact (irritant, permeator). Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering.

EC Risk Phrase

R: 20/21/22 36/37/38 40

EC Safety Phrase

S: 22 24/25 26 36/37/39 45

Exposure Controls/Personal Protection

Personal Protection

Impervious gloves, chemical safety goggles, lab coat.

Exposure Effects

May be harmful if inhaled, absorbed through the skin or swallowed. May cause irritation of the respiratory tract, eyes and skin. May cause damage to the kidneys, liver, heart, GI tract, eyes, central nervous system. May cause birth defects based on animal data.

Accidental Release Measures

Small spills/leaks

Use appropriate tools to put the spilled solid into a waste disposal container. Finish cleaning by spreading water on the contaminated surface.

Stability and Reactivity

Incompatibilities

Oxidizing agents.

Fire Fighting Measures

Fire Potential

May be combustible at high temperature. Extinguish with dry chemical powder, water spray, fog or foam. Do not use water jet. Wear positive pressure SCBA and full turnout gear.