Product Identification

Product Name

4-Pregnene-3,20-dione

Synonyms

(8S,9S,10R,13S,14S,17S)-17-Acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Pregn-4-ene-3,20-dione

CAS

57-83-0

Formula

C21H30O2

Molecular Weight

314.47000000000003

EINECS

200-350-6

RTECS

TW0175000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Hormone

Merck

12,7956

Beilstein/Gmelin

1915949

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Insoluble

Melting Point

127-131

Density

1.17 g/cm3 (25 C)

Usage

The major progestational steroid.

Refractive Index

1.5204

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container. Hormones and antibiotics room.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Store protected from light. Use only in a chemical fume hood.

Hazards Identification

Inhalation

May cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed. May cause irritation of the digestive tract.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear chemical goggles. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear a chemical apron.

Respirators

A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149.

Exposure Effects

Possible cancer hazard based on tests with laboratory animals.

Exposure limit(s)

OSHA: Possible Select carcinogen

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use water spray, dry chemical, or carbon dioxide.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

Stable in air; sensitive to light.

Incompatibilities

Strong oxidizing agents, light.

Decomposition

Carbon monoxide, carbon dioxide.