Product Identification

Product Name

2,6-Dimethylphenyl isocyanate

Synonyms

2,6-Xylyl isocyanate
Benzene, 2-isocyanato-1,3-dimethyl-
Isocyanic acid, 2,6-xylyl ester

CAS

28556-81-2

Formula

C9H9NO

Molecular Weight

147.18

Beilstein/Gmelin

742593

Beilstein Reference

4-12-00-02532

Physical and Chemical Properties

Appearance

Colorless liquid.

Solubility in water

Insoluble

Boiling Point

87-80

Density

1.057 g/cm3 (20 C)

Refractive Index

1.54 (20 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Refrigerator (approx 4 C). Store protected from moisture.

Handling

Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Do not allow contact with water. Wash clothing before reuse. Keep from contact with moist air and steam.

Hazards Identification

Inhalation

Causes respiratory tract irritation. Can produce delayed pulmonary edema.

Skin

Causes skin irritation. Chronic exposure has been associated with an increased incidence of leukemia and multiple myelomas. Immunodepressive effects have been reported. Animal studies have reported fetotoxicity (growth retardation) and teratogenicity (exencephaly, angulated ribs, dilated brain ventricles).

Eyes

Causes eye irritation. Lachrymator. May cause chemical conjunctivitis.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea.

Hazards

Vapors form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff.

EC Risk Phrase

R 23/25 36/37/38 42

EC Safety Phrase

S 23 26 36/37/39 45

UN (DOT)

2206

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Effects may be delayed. Chronic exposure has been associated with an increased incidence of leukemia and multiple myelomas. Immunodepressive effects have been reported. Animal studies have reported fetotoxicity (growth retardation) and teratogenicity (exencephaly, angulated ribs, dilated brain ventricles).

Fire Fighting Measures

Flash Point

86

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Do NOT get water inside containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Provide ventilation. Do not get water inside containers.

Stability and Reactivity

Stability

Stable at room temperature in closed containers under normal storage and handling conditions.

Combustion Products

Fire will produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2206

Hazard Class

6.1

Packing Group

II; III