Product Identification

Product Name

9alpha-Fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregn-1,4-diene-3,20-dione

Synonyms

Aphthasolone
Deltafluorene
Gammacorten
Prednisolone F
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11b,16a)-
Visumetazone

CAS

50-02-2

Formula

C22H29FO5

Molecular Weight

392.47

EINECS

200-003-9

RTECS

TU3980000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data; Hormone

Merck

12,2986

Beilstein/Gmelin

2066651

Physical and Chemical Properties

Appearance

Odorless white to off-white crystalline powder with a slightly bitter taste.

Solubility in water

Insoluble

Melting Point

268 - 271

pKa/pKb

12.14 (pKa)

Usage

Medication.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Use only in a chemical fume hood.

Hazards Identification

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

Causes skin irritation.

Eyes

Causes eye irritation.

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Exposure Controls/Personal Protection

Personal Protection

If Tyvek-type disposable protective clothing is not worn during handling of this chemical, wear disposable Tyvek-type sleeves taped to your gloves.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

seizures have been reported following pulse methylprednisolone therapy.

Fire Fighting Measures

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. A water spray may also be used.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

Has not been fully evaluated.

Incompatibilities

Strong oxidizing agents.

Decomposition

Hydrogen chloride, carbon monoxide, oxides of nitrogen, carbon dioxide.