Product Identification

Product Name

3alpha,7alpha-Dihydroxy-5beta-cholanic acid

Synonyms

17b-(1-Methyl-3-carboxypropyl)etiocholane-3a,7a-diol
3a,7a-Dihydroxy-5b-cholanoic acid
7a-Hydroxylithocholic acid
Anthropodesoxycholic acid
Chenodesoxycholic acid
Cholan-24-oic acid, 3,7-dihydroxy-, (3a,5b,7a)-

CAS

474-25-9

Formula

C24H40O4

Molecular Weight

392.57

EINECS

207-481-8

RTECS

FZ1980000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,2096

Beilstein/Gmelin

3219887

Beilstein Reference

4-10-00-01604

Physical and Chemical Properties

Appearance

White solid.

Solubility in water

Insoluble

Melting Point

164.85 - 165.85

Density

1.162 g/cm3

pKa/pKb

4.76 (pKa)

Usage

Bile acid. A detrrgent used to solubilize fats. Used as cholagogue, a choleretic laxative, and to prevent or dissolve gallstones.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Use only in a chemical fume hood.

Hazards Identification

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

The toxicological properties of this substance have not been fully investigated. May be harmful if swallowed.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Chronic ingestion may cause liver damage. Prolonged or repeated exposure may cause adverse reproductive effects.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, carbon dioxide.