Product Identification

Product Name

5-Azacytidine

Synonyms

1,3,5-Triazin-2(1H)-one, 4-amino-1-b-D-ribofuranosyl-
Antibiotic U 18496
Azacytidine
s-Triazin-2(1H)-one, 4-amino-1-b-D-ribofuranosyl-
Vidaza

CAS

320-67-2

Formula

C8H12N4O5

Molecular Weight

244.21

EINECS

206-280-2

RTECS

XZ3017500

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant

Merck

12,923

Beilstein/Gmelin

620461

Physical and Chemical Properties

Appearance

White crystalline powder.

Solubility in water

Very soluble

Melting Point

235

Boiling Point

478

pKa/pKb

13.69 (pKa)

Partition Coefficient

-1.8

Usage

Used in the treatment of myelodysplastic syndrome.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Deep freeze (below -20 C).

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

Inhalation of dust may cause respiratory tract irritation.

Skin

Causes skin irritation.

Eyes

Dust may cause mechanical irritation.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause blood abnormalities.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

May cause cancer in humans.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, oxides of nitrogen, carbon dioxide.