Product Identification

Product Name

(9alpha,13alpha,14alpha)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one

Synonyms

(9a,13a,14a)-7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one
Cucoline

CAS

115-53-7

Formula

C19H23NO4

Molecular Weight

329.4

EINECS

204-094-6

RTECS

QD2170000

RTECS Class

Drug

Merck

12,8692

Beilstein/Gmelin

95280

Beilstein Reference

5-21-13-00516

Physical and Chemical Properties

Appearance

A toxic crystalline alkaloid from the root of Sinomenium acutum, structurally related to thebaine.

Solubility in water

Insoluble

Melting Point

219 - 221

Boiling Point

513

Vapor Pressure

3E-11 (25 C)

pKa/pKb

9.71 (pKa)

Heat Of Vaporization

81.5 kJ/mol

Usage

Anti-inflammatory.

Refractive Index

 

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If breathing becomes difficult, call a physician.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed. Store in a cool dry place.

Hazards Identification

Inhalation

Material is irritating to mucous membranes and upper respiratory tract.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

45 46 23/24/25 36/37/38

EC Safety Phrase

53 22 26 36/37/39 45

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

May cause cancer. May cause heritable genetic damage. Toxic by inhalation, in contact with skin and if swallowed. Irritating to eyes, respiratory system and skin. Target organ(s): Liver. Kidneys.

Fire Fighting Measures

Flash Point

264

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas, Phosgene gas.