Product Identification

Product Name

2-Butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl methyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one

Synonyms

3H-1,2,4-Triazol-3-one, 4-(4-(4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)- 1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-
Canditral
Oriconazole
Orungal
Sporamelt
Triasporin

CAS

84625-61-6

Formula

C35H38Cl2N8O4

Molecular Weight

705.64

RTECS

XZ5481000

Merck

12,5262

Beilstein/Gmelin

6042047

Physical and Chemical Properties

Appearance

Brown powder.

Solubility in water

Insoluble

Melting Point

166.2

Density

1.40 g/cm3 (20 C)

pKa/pKb

7.53 (pKb)

Partition Coefficient

4.35

Usage

A triazole antifungal agent.

First Aid Measures

Ingestion

Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband.

Inhalation

If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.

Skin

Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.

Eyes

Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs.

Handling and Storage

Storage

Keep container tightly closed. Keep container in a cool, well-ventilated area.

Hazards Identification

Inhalation

May cause irritation.

Skin

May cause irritation.

Eyes

May cause irritation.

Ingestion

May cause nausea or upset stomach, abdominal cramps, vomiting, diarrhea or loose stools. May affect the liver (jaundice/hepatitis, liver function tests impaired). Symptoms may include dermatitis (skin rash/itching), yellow eyes, dark urine, loss of appetite, vertigo, headache, dizziness, depression, paraesthesias, loss of libido, edema (swelling) of the legs or feet, confusion, weakness, excessive tiredness, shortness of breath, cough. It may also cause hypertension, heart failure. It may affect the blood (changes in serum composition), liver, metabolism (weight loss or anorexia, hypokalemia or loss of potassium), and adrenal gland.

EC Risk Phrase

R: 22

EC Safety Phrase

S: 2 46

Exposure Controls/Personal Protection

Personal Protection

Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.

Exposure Effects

May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data.

Fire Fighting Measures

Fire Fighting

Extinguish with carbon dioxide, extinguishing powder or water spray. Fight larger fires with water spray or alcohol resistant foam. Wear self-contained respirator. Wear fully protective impervious suit.

Accidental Release Measures

Small spills/leaks

Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by spreading water on the contaminated surface and dispose of according to local and regional authority requirements.

Stability and Reactivity

Stability

Stable if stored as directed.