Product Identification

Product Name

Yohimbine hydrochloride

Synonyms

Antagonil
Methyl (16alpha,17beta)-17-hydroxyyohimban-16-carboxylate
Yohimban-16-alpha-carboxylic acid, 17-alpha-hydroxy, methyl ester, monohydrochloride
Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, monohydrochloride, (16alpha,17alpha)
Yohimbine hydrochloride

CAS

65-19-0

Formula

C21H27ClN2O3

Molecular Weight

390.9

EINECS

200-600-4

RTECS

ZG1015000

RTECS Class

Human Data

Merck

12,10236

Beilstein/Gmelin

4172596

Physical and Chemical Properties

Appearance

Very slightly yellow needles.

Melting Point

283 - 288

Usage

Improvement of strength, duration and response of male erection, libido enhancement and improved sexual performance.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes. Remove all contaminated clothing immediately.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry place. Keep containers tightly closed.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Do not get in eyes, on skin, or on clothing. Keep container tightly closed. Do not ingest or inhale. Use only in a chemical fume hood. Discard contaminated shoes.

Hazards Identification

Ingestion

May be fatal if swallowed. May cause central nervous system effects and/or neurological effects. May cause hallucinations and distorted perceptions.

Inhalation

May be fatal if inhaled. May cause effects similar to those described for ingestion. May cause respiratory depression.

Skin

May cause skin irritation. May be fatal if absorbed through the skin.

Eyes

May cause eye irritation.

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 25

EC Safety Phrase

S 22 36/37 45

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use carbon dioxide, water spray, or dry chemical.

Fire Potential

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.

Accidental Release Measures

Small spills/leaks

Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable at room temperature in closed containers under normal storage and handling conditions. May decompose when exposed to light.

Incompatibilities

Strong oxidizing agents.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I; II; III