Product Identification

Product Name

Salicylamide

Synonyms

2-Carboxamidophenol
2H-Pyran-2-acetic acid, alpha-ethyl-6-(5-(2-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro(4.1.5.3)pentadec-13-en-9-yl)-2-hydroxy-1,3-dimethyl-4-oxoheptyl)tetrahydro-3,5-dimethyl-
2-Hydroxybenzamide
A-28086A
Algamon
Antibiotic A 28086 factor A
Antibiotic A 28086A
Antibiotic C 7819B
C-7819B
Oramid
Salicylic acid amide
Urtosal

CAS

55134-13-9

CAS

65-45-2

Formula

C43H72O11

Formula

C7H7NO2

Molecular Weight

765.04

Molecular Weight

137.13999999999999

EINECS

200-609-3

RTECS

VN6475000

RTECS

VO8640000

RTECS Class

Drug; Reproductive Effector; Primary Irritant

Merck

12,6506

Merck

12,8480

Beilstein/Gmelin

1678311

Beilstein/Gmelin

742439

Beilstein Reference

4-10-00-00169

Physical and Chemical Properties

Appearance

White or slightly pink crystalline powder.

Solubility in water

2 g/L (20 C)

Melting Point

137

Boiling Point

318

Vapor Pressure

0.0002 (25 C)

Density

1.33 g/cm3 (20 C)

pKa/pKb

8.37 (pKa)

Partition Coefficient

1.28

Heat Of Vaporization

58.2 kJ/mol

Heat Of Combustion

-3352 kJ/mol

Usage

Antibiotic.

Usage

Medication.

Refractive Index

1.562 (20 C)

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Ingestion

May be fatal if swallowed.

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.

Eyes

May cause irritation.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Store at 2 - 8 C. Keep container tightly closed.

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

Inhalation of dust may cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

Causes eye irritation.

Ingestion

May cause irritation of the digestive tract. Overexposure may produce CNS depression, hypotension, eventually respiratory arrest, but does not produce excitement, seizures, acidosis, or hypoprothrombinemia. May be harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

R 22 36/37/38

EC Risk Phrase

28

EC Safety Phrase

28 36/37 45

EC Safety Phrase

S 22 26 36/37/39

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Respirators

Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection,

Exposure Effects

studies with animals indicate that salicylamide overdoses may produce central nervous system depression (rather than CNS stimulation sometimes seen early in salicylate poisonings.)

Exposure Effects

Target organs: heart, skeletal muscles.

Poison Class

3

Fire Fighting Measures

Flash Point

146

Fire Fighting

Extinguish with water spray, carbon dioxide, dry chemical powder or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities

Acids (mineral, non-oxidizing, e.g. hydrochloric acid, hydrofluoric acid, muriatic acid, phosphoric acid), acids (mineral, oxidizing, e.g. chromic acid, hypochlorous acid, nitric acid, sulfuric acid), metals (alkali and alkaline, e.g. cesium, potassium, sodium), metals and metal compounds (toxic, e.g. beryllium, lead acetate, nickel carbonyl, tetraethyl lead), oxidizing agents (strong, e.g. bromine, hydrogen peroxide, nitrogen dioxide, potassium nitrate), reducing agents (strong, e.g. aluminum carbide, chlorosilane, hydrogen phosphide, lithium hydride), water reactive substances (e.g. acetic anyhdride, alkyl aluminum chloride, calcium carbide, ethyl dichlorosilane).

Stability

Stable if stored as directed.

Stability

Stable under normal temperatures and pressures. May discolor on exposure to light.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.

Decomposition

Oxides of carbon.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

II