Product Identification

Product Name

Acetylsalicylic acid

Synonyms

2-(Acetyloxy)benzoic acid
Aspirin
o-Acetylsalicylic acid

CAS

50-78-2

Formula

C9H8O4

Molecular Weight

180.16

EINECS

200-064-1

RTECS

VO0700000

RTECS Class

Drug; Mutagen; Reproductive Effector; Human Data

Merck

13,856

Beilstein/Gmelin

779271

Beilstein Reference

4-10-00-00138

Physical and Chemical Properties

Appearance

Odorless white crystals or crystalline powder with a slightly bitter taste.

Solubility in water

3.3 g/L

Boiling Point

140

Vapor Pressure

.00003

Density

1.39 g/cm3

pKa/pKb

3.49 (pKa)

Partition Coefficient

1.19

Heat Of Vaporization

106.40 kJ/mol

Heat Of Combustion

-3927 kJ/mol

Usage

Medication.

Refractive Index

1.5623 (20 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation. Can produce anaphylactic shock with even small doses.

Skin

May cause skin irritation. Low hazard for usual industrial handling. Chronic ingestion may result in salicylism which is characterized by nausea, vomiting, gastrointestinal ulcers, and hemorrhagic strokes.

Eyes

May cause eye irritation and possible burns.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Inhibits platelet aggregation affecting bleeding

Hazards

Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 22 36/37

EC Safety Phrase

S 26 36/37/39

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Chronic ingestion may result in salicylism which is characterized by nausea, vomiting, gastrointestinal ulcers, and hemorrhagic strokes.

Exposure limit(s)

OEL-UNITED KINGDOM:TWA 5 mg/m3

Poison Class

3

Fire Fighting Measures

Flash Point

250

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: For small fires, use water spray, dry chemical, carbon dioxide or chemical foam.

Fire Potential

This chemical is combustible.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions.

Stability and Reactivity

Stability

Stable under normal shipping and handling conditions.

Incompatibilities

Strong alkali, hydrolyzes in moist air, decomposes in hot water.

Decomposition

Carbon monoxide, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I; II; III