Product Identification

Product Name

2-(4-Imidazolyl)ethylamine dihydrochloride

Synonyms

2-(3H-Imidazol-4-yl)ethanamine dihydrochloride
Ceplene
Histamine dihydrochloride
Peremin

CAS

56-92-8

Formula

C5H11Cl2N3

Molecular Weight

184.06

EINECS

200-298-4

RTECS

MS1575000

RTECS Class

Drug; Reproductive Effector

Merck

13,4739

Beilstein/Gmelin

3624116

Beilstein Reference

4-25-00-02049

Physical and Chemical Properties

Appearance

White crystals.

Melting Point

246

Density

1.43 g/cm3

Usage

Histamine is involved in local immune responses, regulating physiological function in the gut and as a neurotransmitter.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation.

Hazards Identification

Inhalation

Causes respiratory tract irritation. May cause allergic respiratory reaction. May cause effects similar to those described for ingestion. Can produce delayed pulmonary edema. May cause respiratory sensitization.

Skin

Causes skin irritation. May cause an allergic reaction in certain individuals. May cause sensitization by skin contact.

Eyes

Causes eye irritation. May cause chemical conjunctivitis.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause flushing followed by pallor, dizziness, fainting, fall in blood pressure, headache, rapid weak pulse, pain, and itching.

EC Risk Phrase

R 36/37/38 42/43

EC Safety Phrase

S 22 26 36/37/39 45

UN (DOT)

3335

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear safety glasses and chemical goggles if splashing is possible. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Effects may be delayed.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Wash area with soap and water. Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.

Transport Information

UN Number

3335