Product Identification

Product Name

Flagyl

Synonyms

1-(.beta.-Ethylol)-2-methyl-5-nitro-3-azapyrrole
2-(2-Methyl-5-nitro-imidazol-1-yl)ethanol
Acromona
Atrivyl
Bexon
Danizol

CAS

443-48-1

Formula

C6H9N3O3

Molecular Weight

171.16

EINECS

207-136-1

RTECS

NI5600000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,6242

Beilstein/Gmelin

611683

Beilstein Reference

5-23-05-00063

Physical and Chemical Properties

Appearance

White to pale-yellow crystalline powder with a slight odor. Bitter and saline taste.

Solubility in water

1.0 g/100 ml @ 20 C

Melting Point

432 - 435

Partition Coefficient

-0.02 @ 25 C

Usage

Microbiocide.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep containers tightly closed. Store in a cool, dry area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Use only in a chemical fume hood.

Hazards Identification

Inhalation

May cause effects similar to those described for ingestion. May cause irritation of the mucous membranes.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

May cause pain, weakness and numbness with possible muscle paralysis. May cause central nervous system effects. May cause liver damage leading to jaundice. Ingestion of large amounts may cause an increase in blood pressure. May cause tremors, weakness, muscular spasms and ataxia.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Chronic exposure may cause liver damage.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures. May discolor on exposure to light.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.