Product Identification

Product Name

6-Methoxyumbelliferone

Synonyms

6-Methylesculetin
7-Hydroxy-6-methoxy-2H-1-benzopyran-2-one
Chrysatropic acid
Escopoletin
Gelseminic acid
Scopoletol

CAS

92-61-5

Formula

C10H8O4

Molecular Weight

192.17

EINECS

202-171-9

RTECS

GN6930000

RTECS Class

Drug

Merck

12,8552

Beilstein/Gmelin

156296

Beilstein Reference

5-18-03-00203

Physical and Chemical Properties

Appearance

Tan powder.

Solubility in water

Slightly soluble

Melting Point

240

pKa/pKb

9.17 (pKa)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid if irritation or symptoms occur.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep container closed when not in use. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash clothing before reuse.

Hazards Identification

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. The toxicological properties of this substance have not been fully investigated.

Inhalation

Causes upper respiratory tract irritation. Causes irritation of the mucous membrane.

Skin

Causes skin irritation.

Eyes

Causes eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use extinguishing media most appropriate for the surrounding fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.