Product Identification

Product Name

Chloroambucil

Synonyms

4-(Bis(2-Chloroethyl)amino)benzenebutanoic acid
4-(Bis(2-Chloroethyl)amino)phenylbutyric acid
Ambochlorin
Amboclorin
Cb 1348
gamma-(p-bis(2-Chloroethyl)aminophenyl)butyric acid

CAS

305-03-3

Formula

C14H19Cl2NO2

Molecular Weight

304.22000000000003

EINECS

206-162-0

RTECS

ES7525000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,2116

Beilstein/Gmelin

999011

Beilstein Reference

4-14-00-01715

Physical and Chemical Properties

Appearance

White to pale beige crystalline or granular powder with a slight odor.

Solubility in water

Insoluble

Melting Point

69

Boiling Point

424

pKa/pKb

5.75 (pKa)

Partition Coefficient

4.07

Usage

Medication (vet).

First Aid Measures

Ingestion

If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. MMEDIATELY transport the victim to a hospital.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Symptoms of exposure to this compound include leukemia, dyspnea, cough, interstitial fibrosis and menstrual cycle changes or disorders. It may cause keratitis epithelialis in association with exfoliative dermatitis and reversible pseudotumor cerebri with papilledema. It may also cause vomiting, lethargy and unconsciousness with grand mal seizures.

Skin

See inhalation.

Eyes

See inhalation

Ingestion

See inhalation.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Wear a NIOSH-approved half face respirator equipped with a combination filter cartridge, i.e. organic vapor/acid gas/HEPA (specific for organic vapors, HCl, acid gas, SO2 and a high efficiency particulate filter).

Exposure Effects

Seizures have been reported in both adults and children. Onset is within 1.5 To 5 hours. Ataxia, agitation, irritability, and coma have all been reported. This agent is thought to cross the placenta and to be teratogenic producing unilateral renal agenesis. Chlorambucil also causes chromosomal damage in man.

Fire Fighting Measures

Fire Fighting

Fires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher.

Fire Potential

This material is nonflammable

Accidental Release Measures

Small spills/leaks

Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Incompatibilities

Reacts with proteins and a variety of nucleophilic compounds.

Stability

Sensitive to light and heat.