Product Identification

Product Name

Melatonine

Synonyms

5-Methoxy-N-acetyltryptamine
Circadin
Melovine
N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
N-Acetyl-5-methoxytryptamine
Regulin

CAS

73-31-4

Formula

C13H16N2O2

Molecular Weight

232.28

EINECS

200-797-7

RTECS

AC5955000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Hormone

Merck

12,5857

Beilstein/Gmelin

205542

Beilstein Reference

5-22-12-00042

Physical and Chemical Properties

Appearance

Yellow to beige powder. Natural hormone produced by the penal grand.

Solubility in water

Insoluble

Melting Point

116 - 118

Density

1.272 g/cm3

pKa/pKb

12.60 (pKb)

Partition Coefficient

1.198

Usage

Sleeping aid.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. Get medical aid if cough or other symptoms appear.

Skin

Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Inhalation

May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Hazards

During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures

Small spills/leaks

Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.

Stability and Reactivity

Disposal Code

3

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.

Transport Information

HS Code

2937 90 00