Product Identification

Product Name

Amoxapine

Synonyms

2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine
8-Chloro-6-piperazin-1-ylbenzo[b][1,5]benzoxazepine
Amoxan
Asendin
Moxadil

CAS

14028-44-5

Formula

C17H16ClN3O

Molecular Weight

313.79000000000002

EINECS

237-867-1

RTECS

HQ4025500

RTECS Class

Drug; Human Data

Merck

12,616

Beilstein/Gmelin

832057

Beilstein Reference

6-27

Physical and Chemical Properties

Appearance

White solid

Solubility in water

Insoluble

Melting Point

175 - 176

Boiling Point

470

Vapor Pressure

5E-9 (25 C)

pKa/pKb

5.97 (pKb)

Heat Of Vaporization

73.2 kJ/mol

Usage

Tricyclic antidepressant.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of skin contact, flush with copious amounts of water for at least 15 minutes. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Keep tightly closed.

Hazards Identification

Inhalation

May be harmful if inhaled. Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Ingestion

Harmful if swallowed.

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

22

EC Safety Phrase

36

Exposure Controls/Personal Protection

Personal Protection

Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves.

Exposure Effects

Harmful if swallowed. Calif. Prop. 65 reproductive hazard. Target organ(s): Heart. Central nervous system.

Fire Fighting Measures

Flash Point

238

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.