Product Identification

Product Name

(2R)-2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-isopropylpentanenitrile

Synonyms

2-(3,4-Dimethoxyphenyl)-5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-ylpentanenitrile
5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-(3,4-dimethoxyphenyl)-2-isopropylpentanenitrile
Dilacoran

CAS

52-53-9

Formula

C27H38N2O4

Molecular Weight

454.61

EINECS

200-145-1

RTECS

YV8300000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,10083

Beilstein/Gmelin

2825000

Physical and Chemical Properties

Appearance

Viscous, pale yellow oil.

Solubility in water

practically insoluble

Boiling Point

232 - 235 (0.01 torr)

pKa/pKb

8.6(at 25℃) (pKa)

Usage

Calcium channel blocker.

Refractive Index

1.5448 (25 C)

First Aid Measures

Ingestion

Flush mouth with water. See medical assistance.

Inhalation

Remove to fresh air.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush with water and seek medical assistance.

Handling and Storage

Storage

Store in a cool, dry location in a tightly closed container.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Hazards Identification

Inhalation

Respiratory effects are uncommon but noncardiogenic pulmonary edema, may occur following significant overdose.

Skin

Causes irritation. Flushing is common with nifedipine.

Eyes

Causes irritation.

Ingestion

Nausea and vomiting occur frequently. Ileus can also occur. Concretions from sustained-release dosage forms have been found at autopsy. Bowel infarction has also been reported.

Exposure Controls/Personal Protection

Personal Protection

Latex gloves, chemical safety goggles and disposable protective clothing.

Respirators

A NIOSH approved respirator should be available.

Exposure Effects

CNS depression, secondary to hemodynamic instability occurs following significant overdose. Effects may include drowsiness, confusion, and coma. Cerebral infarction has been reported.

Fire Fighting Measures

Fire Fighting

Wear self contained breathing apparatus and protective clothing. Use water spray, carbon dioxide, dry chemical or foam to extinguish fire.

Accidental Release Measures

Small spills/leaks

While wearing recommended personal protective equipment, absorb liquid with paper and place in a container for disposal.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Combustion Products

May emit toxic fumes.