Product Identification

Product Name

Ranitidine hydrochloride

Synonyms

1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N-methyl-2-nitro-
N-(2-(((-5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine

CAS

66357-35-5

Formula

C13H22N4O3S

Molecular Weight

314.41000000000003

EINECS

266-332-5

RTECS

KM6556500

RTECS Class

Drug; Human Data

Merck

12,8286

Beilstein/Gmelin

4327819

Physical and Chemical Properties

Appearance

Off-whice to pale yellow powder with a characteristic sulfur-like odor.

Solubility in water

water soluble

Melting Point

69-70

Partition Coefficient

-1.1

Usage

Medication.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Ranitidine hydrochloride tablets or solution should be stored in a dry place at 15-30C in tight, light-resistant containers.

Handling

Use practices that will minimize dust generation and contact.

Hazards Identification

Ingestion

Respiratory depression may occur.

Inhalation

Respiratory depression may occur.

Skin

Occupational dermatitis and psoriasis have been reported.

Eyes

Causes irritation.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

NIOSH/MSHA recommended respirator.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Wear full protective equipment. Collect by carefully sweeping or vacuuming with HEPA filtered vacuum and place in a labeled, sealed container for disposal. Was area with water.

Stability and Reactivity

Stability

No data.

Incompatibilities

Strong oxidizing agents.

Decomposition

Toxic and corrosive vapores, chlorides, oxides of nitrogen and sulfur.