Product Identification

Product Name

3-(3,4-Dihydroxyphenyl)-2-hydrazinyl-2-methyl-propanoic acid

Synonyms

Hydrazino-a-methyldopa
L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic acid
L-a-Hydrazino-a-methyl-b-(3,4-dihydroxyphenyl)propionic acid
L-alpha-Methyldopahydrazine
N-Aminomethyldopa
S-(-)-a-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid

CAS

28860-95-9

Formula

C10H16N2O5

Molecular Weight

244.25

EINECS

249-271-9

RTECS

MW5298000

RTECS Class

Drug; Mutagen; Reproductive Effector

Merck

12,1843

Beilstein/Gmelin

657532

Beilstein Reference

5-15

Physical and Chemical Properties

Solubility in water

Very soluble

Melting Point

206 - 208

Boiling Point

419

Vapor Pressure

5E-12 (25 C)

pKa/pKb

3.40 (pKa)

Partition Coefficient

.46

Heat Of Vaporization

84.6 kJ/mol

Usage

Peripheral inhibitor ofl-aromatic amino acid decarboxylase. When administered simultaneously withl-dopa, it prevents extracerebral conversion to dopamine.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water.

Eyes

In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.

Handling and Storage

Storage

Keep tightly closed. Store in a cool dry place. Store at -20 C

Hazards Identification

Inhalation

Material may be irritating to mucous membranes and upper respiratory tract.

Skin

May cause skin irritation.

Eyes

May cause eye irritation.

Hazards

Emits toxic fumes under fire conditions.

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles.

Respirators

Government approved respirator.

Exposure Effects

Avoid contact and inhalation.

Fire Fighting Measures

Fire Fighting

Extinguish using Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Nitrogen oxides.