Product Identification

Product Name

Provitamine D2

Synonyms

delta-5,7,22-Ergostatrien-3beta-ol
Ergosta-5,7,22-trien-3-beta-ol
Ergosta-5:6,7:8,22:23-trien-3-ol
Ergosterin
Provitamin D
Provitamin D2

CAS

57-87-4

Formula

C28H44O

Molecular Weight

396.66

EINECS

200-352-7

Merck

12,3701

Beilstein/Gmelin

2062413

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Insoluble

Melting Point

162

Boiling Point

502

Vapor Pressure

4E-12 (25 C)

Density

1.04 g/cm3 (20 C)

Partition Coefficient

9.34

Heat Of Vaporization

88.7 kJ/mol

Usage

Chemical intermediate for vitamin d2.

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Keep container closed when not in use. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

Inhalation of dust may cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

Dust may cause mechanical irritation.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause headache, nausea, fatigue, and dizziness. Ingestion of large amounts of vitamin D may result in hypercalcemia.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Prolonged hypercalcemia may result in a deposition of calcium salts in the soft tissues, most significantly the kidney.

Fire Fighting Measures

Flash Point

216

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water fog, dry chemical, carbon dioxide, or regular foam. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures. Substance undergoes color change upon exposure to light and air.

Incompatibilities

Strong oxidizing agents, acids.

Decomposition

Carbon monoxide, carbon dioxide.