Product Identification

Product Name

2-(p-Aminobenzenesulfonamido)thiazole

Synonyms

1,6-Dehydro-6-chlororetroprogesterone
2-(p-Aminobenzenesulfonamido)thiazole
2-(p-Aminobenzenesulphonamido)thiazole
4-Amino-n-2-thiazolylbenzenesulfonamide
6-Chloro-1,6-dehydroretroprogesterone
Azoquimiol
Azoseptale
Pregna-1,4,6-triene-3,20-dione, 6-chloro-, (9b,10a)-
Retroid
Ro 4-8347

CAS

5192-84-7

CAS

72-14-0

Formula

C21H25ClO2

Formula

C9H9N3O2S2

Molecular Weight

255.32

Molecular Weight

344.88

EINECS

200-771-5

EINECS

225-978-8

RTECS

WP2360000

RTECS Class

Tumorigen; Mutagen; Reproductive Effector; Human Data

Merck

12,9115

Merck

12,9717

Beilstein/Gmelin

226178

Beilstein Reference

4-27-00-04623

Physical and Chemical Properties

Appearance

White crystalline powder.

Solubility in water

Slightly soluble

Solubility in water

1.9 mg/L (25 C)

Melting Point

199 - 202

Boiling Point

479

Boiling Point

480

Vapor Pressure

2.5E-9 (25 C)

Vapor Pressure

2E-9 (25 C)

Density

1.20 g/cm3 (20 C)

Density

1.61 g/cm3

pKa/pKb

7.24 (pKa)

Partition Coefficient

4.27 (25 C)

Partition Coefficient

.05

Heat Of Vaporization

74.28 kJ/mol

Heat Of Vaporization

74.4 kJ/mol

Usage

Medication (vet).

Refractive Index

1.674

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

Handling and Storage

Storage

Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.

Handling

All chemicals should be considered hazardous. Avoid direct physical contact. Use appropriate, approved safety equipment. Untrained individuals should not handle this chemical or its container. Handling should occur in a chemical fume hood.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Exposure Effects

headache, depression, and hallucinations have been reported with therapeutic use of sulfonamides. Coma and seizures were reported following a large overdose of sulfasalazine in one patient. Tremor occurred in one patient following a fixed-dose combination of trimethoprim/sulfamethoxazole.

Fire Fighting Measures

Flash Point

201

Flash Point

244

Fire Fighting

Fires involving this compound should be controlled with a dry chemical, carbon dioxide or halon extinguisher.

Accidental Release Measures

Small spills/leaks

Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Stability and Reactivity

Stability

No data.

Transport Information

HS Code

2935 00 90

Hazards Identification

Ingestion

Nausea and vomiting are likely to occur.