Product Identification

Product Name

4-Nitro-2-chloroaniline

Synonyms

1-amino-2-chloro-4-nitrobenzene
2-Chloro-4-nitrobenzenamine

CAS

121-87-9

Formula

C6H5ClN2O2

Molecular Weight

172.58

EINECS

204-502-2

RTECS

BX1400000

RTECS Class

Mutagen

Beilstein/Gmelin

638657

Beilstein Reference

4-12-00-01675

EC Index Number

610-009-00-7

EC Class

Harmful; Dangerous for the Environment

Physical and Chemical Properties

Appearance

Yellow crystalline powder.

Solubility in water

0.23 g/L

Melting Point

105

Boiling Point

326

Vapor Pressure

0.0002 (25 C)

Density

1 g/cm3 (20 C)

Partition Coefficient

2.14

Heat Of Vaporization

56.8 kJ/mol

Usage

Intermediate in manufacture of dyes.

Vapor Density

5.9

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.

Skin

Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Take precautionary measures against static discharges. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death. May cause liver and kidney damage. May cause cardiac abnormalities. Inhalation at high concentrations may cause CNS depression and asphixiation.

Skin

Absorption into the body may cause cyanosis. Causes redness and pain.

Eyes

May cause eye irritation. Causes redness and pain.

Ingestion

May cause irritation of the digestive tract. May cause liver and kidney damage. May cause cardiac disturbances. May cause methemoglobinemia, cyanosis, convulsions, and death. May cause headache. May cause nausea and vomiting. May cause central nervous system depression.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

EC Risk Phrase

R 22 51/53

EC Safety Phrase

S 22 24 61

UN (DOT)

2237

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

May cause liver and kidney damage. May cause methemoglobinemia, which is characterized by chocolate-brown colored blood, headache, weakness, dizziness, breath shortness, cyanosis, rapid heart rate, unconsciousness and possible death. Effects may be delayed. May cause cyanosis - a blue-gray coloring of the skin and lips caused by a lack of oxygen.

Exposure limit(s)

2 ppm TWA ACGIH

Fire Fighting Measures

Flash Point

151

Autoignition

522

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Dusts at sufficient concentrations can form explosive mixtures with air. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Containers may explode when heated. Runoff from fire control or dilution water may cause pollution. Extinguishing media: For small fires, use dry chemical, carbon dioxide, or water spray. For large fires, use dry chemical, carbon dioxide, alcohol-resistant foam, or water spray. Cool containers with flooding quantities of water until well after fire is out.

Fire Potential

Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, using the appropriate protective equipment. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Incompatibilities

Oxidizing agents, strong acids, strong bases.

Stability

Stable at room temperature in closed containers under normal storage and handling conditions.

Decomposition

Hydrogen chloride, nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2237

Hazard Class

6.1

Packing Group

III