Product Identification

Product Name

4-Acetophenetidine

Synonyms

4-Acetophenetidide
4'-Ethoxyacetanilide
N-(4-Ethoxyphenyl)acetamide
p-Acetophenetidide
R-227ca

CAS

62-44-2

CAS

2252-84-8

Formula

C10H13NO2

Formula

C3HF7

Molecular Weight

170.03

Molecular Weight

179.22

EINECS

200-533-0

RTECS

AM4375000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,7344

Beilstein/Gmelin

1869238

Beilstein/Gmelin

1701755

Beilstein Reference

4-01-00-00188

Beilstein Reference

4-13-00-01092

Physical and Chemical Properties

Appearance

Odorless fine white crystalline solid with a lightly bitter taste.

Solubility in water

800 m8 g/L

Solubility in water

Slightly soluble

Melting Point

134-135

Melting Point

-145

Boiling Point

-14

Boiling Point

355

Vapor Pressure

260 (185 C)

Vapor Pressure

3100 (25 C)

Density

1.2404

Partition Coefficient

1.58

Partition Coefficient

1.74

Heat Of Vaporization

22.6 kJ/mol

Heat Of Vaporization

60.0 kJ/mol

Heat Of Combustion

-5455 kJ/mol

Usage

Analgesic.

Usage

Refrigerant.

Refractive Index

1.505 (20 C)

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Ingestion

Seek medical assistance.

Inhalation

Vapors may cause dizziness or asphyxiation without warning.

Inhalation

Move victim to fresh air. Apply artificial respiration if victim is not breathing. Administer oxygen if breathing is difficult.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.

Skin

Remove and isolate contaminated clothing and shoes. In case of contact with liquefied gas, thaw frosted parts with lukewarm water.

Skin

Contact with gas or liquefied gas may cause burns, severe injury and/or frostbite.

Eyes

See Skin.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

Unlikely to occur.

Inhalation

May cause respiratory tract irritation. May cause methemoglobinemia, cyanosis, convulsions, tachycardia, dyspnea, and death.

Skin

May cause skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May produce mucosal lesions.

Eyes

May cause eye irritation.

Ingestion

May cause irritation of the digestive tract. May cause kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness, and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Methemoglobinemia is characterized by dizziness, drowsiness, headache, breath shortness, cyanosis with bluish skin, rapid heart rate and chocolate-brown colored blood. May cause sideroblastic anemia and hemolytic anemia. May result in Stevens-Johnson syndrome. Ingestion of large amounts may cause cyanosis, respiratory depression and cardiac arrest.

Hazards

Vapors from liquefied gas are initially heavier than air and spread along ground.

EC Safety Phrase

S 23 38

UN (DOT)

3163

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Personal Protection

Wear appropriate protective gloves, clothing and goggles.

Respirators

Wear positive pressure self-contained breathing apparatus (SCBA).

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

Chronic ingestion may cause effects similar to those of acute ingestion. Chronic exposure may lead to weight loss, shortness of breath, weakness, and often aplastic anemia. Experimental carcinogen.

Fire Fighting Measures

Flash Point

168

Flash Point

-49

Fire Fighting

Use extinguishing agent suitable for type of surrounding fire.

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Fire Potential

May burn but does not ignite readily

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation.

Small spills/leaks

Prevent any contact with the spilled material. Stop leak if you can do it without risk. Do not direct water at spill or source of leak. If possible, turn leaking containers so that gas escapes rather than liquid. Allow substance to evaporate and vntilate the area.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents - strong acids - strong bases.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

3163