Product Identification

Product Name

Niclosamide

Synonyms

2',5-Dichloro-4'-nitrosalicylanilide
2-Chloro-4-nitrophenylamide-6-chlorosalicylic acid
2-Hydroxy-5-chloro-n-(2-chloro-4-nitrophenyl)benzamide
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Benzamide, 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy

CAS

50-65-7

Formula

C13H8Cl2N2O4

Molecular Weight

327.12

EINECS

200-056-8

RTECS

VN8400000

RTECS Class

Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector

Merck

12,6602

Beilstein/Gmelin

2820605

Physical and Chemical Properties

Appearance

Pale, yellow crystals.

Solubility in water

5-8 mg/L at 20 C

Melting Point

225-230

Partition Coefficient

10 @ pH 9.6

Usage

Medication, molluscicide.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Irrigate exposed eyes with copious amounts of tepid water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility.

Handling and Storage

Storage

Stored at a temperature less than 30C; freezing of the tablets should be avoided.

Handling

Avoid eye and skin contact. Do not smoke or eat while using. Wear eye protection (face visor or goggles) if accidental eye contact can occur. Observe good personal hygiene. Avoid breathing dust.

Hazards Identification

Ingestion

May cause nausea, vomiting, abdominal pain, taste disturbances, fatigue, headache, confusion, insomnia, dizziness, fever, an influenza-like syndrome, arthralgia, muscle pain, hypotension, vasculitis and skin rash.

Inhalation

Not considered hazardous under normal conditions of use. May cause same health side effects as when swallowed.

Skin

Not considered hazardous under normal conditions of use. Contact may cause skin irritation.

Eyes

Contact may cause temporary stinging or redness.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Use NIOSH/MSHA approved respirator appropriate for exposure of concern.

Poison Class

4

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Sweep or vacuum. Place in bag and dispose of waste in compliance with local waste disposal regulations. Ventilate area and wash spill site after material pick-up is complete.

Stability and Reactivity

Incompatibilities

Strong oxidizing agents.

Stability

Tablets are sensitive to moisture. Decomposes more rapidly in the presence of UV irradiation. It is stable to heat and is hydrolysed by concentrated acid or alkali.