Product Identification

Product Name

Captopril

Synonyms

(2S)-1-(3-Mercapto-2-methylpropionyl)-L-proline
(2S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
Acepress
Acepril
Alopresin
Capoten

CAS

62571-86-2

Formula

C9H15NO3S

Molecular Weight

217.29

EINECS

263-607-1

RTECS

UY0550000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,1817

Beilstein/Gmelin

477887

Physical and Chemical Properties

Appearance

White to off-white, crystalline powder. Slight acid-sulfhydryl odor.

Solubility in water

freely soluble

Melting Point

103 - 105

pKa/pKb

3.7 (pKa)

Partition Coefficient

.34

Usage

Antihypertensive drug.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Ingestion

May cause irritation of the digestive tract.

Inhalation

Causes respiratory tract irritation. Inhalation may be fatal as a result of spasm, inflammation, edema of the larynx and bronchi, chemical pneumonitis and pulmonary edema. May be harmful if inhaled. May cause burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.

Skin

Causes skin irritation. May be harmful if absorbed through the skin. May cause sensitization by skin contact.

Eyes

Causes eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Extinguishing media: Use foam, dry chemical, or carbon dioxide.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

Stable under normal shipping and handling conditions.

Incompatibilities

Strong oxidizing agents, acids, acid chlorides, carbon dioxide, acid anhydrides.

Decomposition

Carbon monoxide, oxides of nitrogen, oxides of sulfur, carbon dioxide.