Product Identification

Product Name

Formestane

Synonyms

4-Hydroxy-4-androstene-3,17-dione
4-Hydroxy-delta(sub 4)-androstenedione
CGP-32349

CAS

566-48-3

Formula

C19H26O3

Molecular Weight

302.41000000000003

RTECS

BV8152500

Merck

12,4267

Beilstein/Gmelin

1889793

Physical and Chemical Properties

Appearance

White powder.

Solubility in water

Insoluble

Melting Point

199 - 202

Vapor Pressure

4.9E-11 (25 C)

Density

1.19 g/cm3 (20 C)

pKa/pKb

9.31 (pKa)

Partition Coefficient

2.66

Usage

Used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water, provided person is conscious. Seek medical advice.

Inhalation

Remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen. Seek medical attention.

Skin

Immediately wash skin with soap and copious amounts of water for at least 15 minutes. If irritation persists, seek medical attention.

Eyes

Immediately flush eyes with copious amounts of water for at least 15 minutes. Seek medical advice.

Handling and Storage

Storage

Store cool, dark and dry.

Exposure Controls/Personal Protection

Personal Protection

Wear self-contained breathing apparatus, rubber boots & heavy rubber gloves.

Exposure Effects

Harmful by inhalation, in contact with skin and if swallowed.

Fire Fighting Measures

Fire Fighting

Extinguish with carbon dioxide, dry chemical powder or appropriate foam. Water spray. Wear self-contained breathing apparatus and protective clothing to prevent contact with the skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep-up/absorb in suitable material, place in a container and hold for disposal. Avoid raising dust. Ventilate area and wash spill site after pickup is complete.

Stability and Reactivity

Combustion Products

Emits toxic fumes under fire conditions.

Hazards Identification

EC Risk Phrase

R: 20/21/22

EC Safety Phrase

S: 36/37