Product Identification

Product Name

Nifedipine

Synonyms

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester
Adalat
Calcigard
Cardifen
Dimethyl 4-(o-Nitrophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
Procardia XL

CAS

21829-25-4

Formula

C17H18N2O6

Molecular Weight

346.34

EINECS

244-598-3

RTECS

US7975000

RTECS Class

Drug; Reproductive Effector; Human Data

Merck

12,6617

Beilstein/Gmelin

497773

Beilstein Reference

5-22-04-00268

Physical and Chemical Properties

Appearance

Odorless yellow crystals or powder. Tasteless.

Solubility in water

Insoluble

Melting Point

172 - 174

Boiling Point

475

Vapor Pressure

.000000003

pKa/pKb

10.07 (pKb)

Partition Coefficient

3.17

Heat Of Vaporization

72.9 kJ/mol

Usage

Used to treat high blood pressure by relaxing blood vessels.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a tightly closed container. Refrigerator (approx 4 C).

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Ingestion

Harmful if swallowed. May cause irritation of the digestive tract.

Inhalation

May cause respiratory tract irritation. May be harmful if inhaled.

Skin

May cause skin irritation. May be harmful if absorbed through the skin.

Eyes

May cause eye irritation.

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Flash Point

240

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.