Product Identification

Product Name

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone

Synonyms

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine
AC-1075
Alexan
Arabinocitidine
Ara-C
Cytarabin

CAS

147-94-4

Formula

C9H13N3O5

Molecular Weight

243.22

EINECS

205-705-9

RTECS

HA5425000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant

Merck

12,2853

Beilstein/Gmelin

89175

Beilstein Reference

4-25-00-03669

Physical and Chemical Properties

Appearance

White to off white, lyophilized powder. Odorless.

Solubility in water

Soluble.

Melting Point

223 - 224

Partition Coefficient

-2.18

Usage

Antileukemic agent.

First Aid Measures

Ingestion

DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician.

Inhalation

IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used.

Skin

IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.

Eyes

First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

Handling and Storage

Storage

Store in a tightly closed container in a cool area.

Handling

Avoid all fors of unprotected contact when mixing and administering this product.

Hazards Identification

Inhalation

Adult respiratory distress syndrome has been reported. Causes irritation. Poisonous.

Skin

Rash is a common adverse effect of cytarabine therapy. Poisonous on contact.

Eyes

Irritation.

Ingestion

Poisonous.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

Wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter.

Exposure Effects

with therapeutic use - CNS toxicity is associated with high dose cytarabine therapy, and includes cerebral and cerebellar dysfunction. Peripheral neuropathy may develop. Teratogenicity has been reported in animal studies.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator.

Stability and Reactivity

Stability

Stable.

Incompatibilities

Strong oxidizing agents.

Decomposition

Emits toxic fumes when heated.