Product Identification

Product Name

2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid

Synonyms

4-Pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-
4-Pyrimidinecarboxylic acid, 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-
5-Fluoro-2,6-dioxo-3H-pyrimidine-4-carboxylic acid
5-Fluoroorotate
NSC 31712
WR 152520

CAS

703-95-7

Formula

C5H3FN2O4

Molecular Weight

174.09

EINECS

211-876-0

RTECS

UV7800000

RTECS Class

Drug

Merck

13,4203

Beilstein/Gmelin

181933

Beilstein Reference

5-25-08-00240

Physical and Chemical Properties

Appearance

Solid.

Solubility in water

Very soluble

Melting Point

260 - 262

pKa/pKb

2.04 (pKa)

Partition Coefficient

-1

Heat Of Vaporization

Usage

Research tool in molecular genetics.

First Aid Measures

Ingestion

Get medical aid. Wash mouth out with water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes.

Eyes

Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Store in a tightly closed container.

Handling

Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.

Hazards Identification

Ingestion

May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.

Inhalation

Causes respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.

Skin

Causes skin irritation.

Eyes

Causes eye irritation.

EC Risk Phrase

R 22

EC Safety Phrase

S 22 36/37

Exposure Controls/Personal Protection

Personal Protection

Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Accidental Release Measures

Small spills/leaks

Vacuum or sweep up material and place into a suitable disposal container.

Stability and Reactivity

Stability

Stable under normal shipping and handling conditions.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen fluoride.