Product Identification

Product Name

Colchicine

Synonyms

7-alpha-H-Colchicine
Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-(S)-
Benzo[a]heptalen-9(5H)-one
Colchineos
N-Acetyl trimethylcolchicinic acid methyl ether

CAS

64-86-8

Formula

C22H25NO6

Molecular Weight

399.44

EINECS

200-598-5

RTECS

GH0700000

RTECS Class

Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector; Human Data; Primary Irritant

Merck

12,2536

Beilstein/Gmelin

2228813

Beilstein Reference

4-14-00-00946

EC Index Number

614-005-00-6

EC Class

Very toxic

Physical and Chemical Properties

Appearance

Pale yellow scales or powder; pale yellow needles when crystallized from odorless or nearly so.

Solubility in water

50 g/L

Melting Point

154 - 156

Density

1.32 g/cm3

pKa/pKb

12.36(at 20℃) (pKa)

Usage

In research in plant genetics (for doubling chromosomes).

Vapor Density

14

First Aid Measures

Ingestion

If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.

Inhalation

Remove from exposure to fresh air immediately. Get medical aid if cough or other symptoms appear.

Skin

Get medical aid if irritation develops or persists. Flush skin with plenty of soap and water.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.

Handling and Storage

Storage

Do not store in direct sunlight. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store below 40C.

Handling

Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Inhalation

Causes respiratory tract irritation.

Skin

Causes skin irritation.

Eyes

Causes eye irritation.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause kidney damage. May cause systemic toxicity with acidosis. Exposure may cause anemia and other blood abnormalities. May produce aplastic anemia, blood pressure depression, body temperature decrease, changes in kidnet tubules, dyspnea, flaccid paralysis without anesthesia, gastrointestinal effects, kidney damage and hemorrhaging, muscle contraction or spasticity, muscle weakness, nausea, vomiting, respiratory stimulation and somnolence. Prolonged ingestion may produce bone marrow depression with agranulocytosis, thrombocytopenia, leukopenia and aplastic anemia may occur with prolonged administration. Lab findings in overdoses have indicated metabolic acidosis, hyponatremia, hypokalemia, bone marrow hypoplasia, thrombocytopenia, granulocytopenia, coagulopathy, and less commonly hemolytic anemia.

Hazards

Stable.

UN (DOT)

2811

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Exposure Effects

May cause bone marrow abnormalities with damage to blood forming tissues.

Poison Class

1*

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. To extinguish fire use water spray, dry chemical, carbon dioxide, or chemical foam.

Fire Potential

Slight fire hazard.

Accidental Release Measures

Small spills/leaks

Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions.

Stability and Reactivity

Stability

Stable under normal shipping and handling conditions.

Incompatibilities

Strong oxidizing agents.

Decomposition

Nitrogen oxides, carbon monoxide, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2811

Hazard Class

6.1

Packing Group

I; II; III