Product Identification

Product Name

6a,9a-Fifluoro-16a,17a-isopropylidenedioxy-1,4-pregnadiene-3,20-dione

Synonyms

6a,9a-Difluoro-16a-hydroxyprednisolone 16,17-acetonide
6a-Fluorotriamcinolone acetonide
Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,12-dihydroxy-16, 17-[(1-methylethylidene)bis(oxy)]-, (6.alpha.,11.beta., 16.alpha.)-
Sinalar
Synandone

CAS

67-73-2

Formula

C24H30F2O6

Molecular Weight

452.5

EINECS

200-668-5

RTECS

TU3830000

RTECS Class

Drug; Mutagen; Reproductive Effector

Merck

12,4185

Beilstein/Gmelin

1358395

Beilstein Reference

5-19-06-00571

Physical and Chemical Properties

Solubility in water

Insoluble

Melting Point

267 - 269

Boiling Point

579

Vapor Pressure

9E-16 (25 C)

pKa/pKb

12.55 (pKa)

Heat Of Vaporization

99.4 kJ/mol

Usage

A synthetic steroid used as an anti-inflammatory and anti-pruritic agent.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen

Handling and Storage

Storage

Keep tightly closed. Store in a cool dry place.

Hazards Identification

Inhalation

Material is irritating to mucous membranes and upper respiratory tract.

Skin

Causes irritation. Toxic if absorbed through the skin.

Eyes

Causes irritation.

Ingestion

Harmful/toxic if swallowed

Hazards

Emits toxic fumes under fire conditions.

EC Risk Phrase

20/21/22 36/37/38 40

EC Safety Phrase

22 26 36

Exposure Controls/Personal Protection

Personal Protection

Evacuate area. Wear self-contained breathing apparatus, rubber boots, and heavy rubber gloves. Wear disposable coveralls and discard them after use.

Exposure Effects

Limited evidence of a carcinogenic effect Possible teratogen. Possible mutagen.

Fire Fighting Measures

Flash Point

304

Fire Fighting

Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. Do not breathe dust. Do not get in eyes, on skin, on clothing. Avoid prolonged or repeated exposure.

Stability and Reactivity

Incompatibilities

Strong oxidizing agents.

Decomposition

Carbon monoxide, Carbon dioxide, Hydrogen fluoride.