Product Identification

Product Name

N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid

Synonyms

4-Aminofolic acid
4-Aminopteroylglutamic acid
L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-

CAS

54-62-6

Formula

C19H20N8O5

Molecular Weight

440.42

EINECS

200-209-9

RTECS

MA1050000

RTECS Class

Agricultural Chemical and Pesticide; Tumorigen; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,493

Beilstein/Gmelin

69045

Beilstein Reference

4-26-00-03831

Physical and Chemical Properties

Appearance

Clusters of yellow needles.

Melting Point

260-265

pKa/pKb

3.52 (pKa)

Partition Coefficient

.15

Usage

Is a folic acid antagonist.

First Aid Measures

Ingestion

Seek medical attention. If individual is drowsy or unconscious, do not give anything by mouth; place individual on the left side with the head down. Contact a physician, medical facility, or poison control center for advice about whether to induce vomiting. If possible, do not leave individual unattended.

Inhalation

If symptoms develop, move individual away from exposure and into fresh air. If symptoms persist, seek medical attention. If breathing is difficult, administer oxygen. Keep person warm and quiet; seek immediate medical attention.

Skin

Remove contaminated clothing. Wash exposed area with soap and water. If symptoms persist, seek medical attention. Launder clothing before reuse.

Eyes

If symptoms develop, immediately move individual away from exposure and into fresh air. Flush eyes gently with water for at least 15 minutes while holding eyelids apart; seek immediate medical attention.

Handling and Storage

Storage

Cool dry location in a tightly sealed container. Avoid exposure to light.

Handling

Do not breath dust, get in eyes, on skin or on clothing. Avoid prolonged or repeated exposure. Always work in a chemical hood and while using the recommended protective equipment.

Hazards Identification

Inhalation

May be fatal if inhaled, ingested or absorbed through the skin. Causes irritation.

Skin

See inhalation.

Eyes

See inhalation

Ingestion

See inhalation.

Exposure Controls/Personal Protection

Personal Protection

Chemical splash goggles in compliance with OSHA regulations are advised; however, OSHA regulations also permit other type safety glasses. Whre chemical resistant gloves. To prevent repeated or prolonged skin contact, wear impervious clothing and boots.

Respirators

NIOSH/MSHA approved respirator.

Exposure Effects

Chronic exposure may cause congenitial malformations of the fetus. Studies havs shown mutagenic effects. Causes blood effects.

Poison Class

1*

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use agent most appropriate to extinguish fire.

Accidental Release Measures

Small spills/leaks

Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors. Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal. Small dry spills: with clean shovel place material into clean, dry container and cover; move containers from spill area. Large spills: dike far ahead of spill for later disposal.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Incompatibilities

Strong oxidizing agents.

Decomposition

Oxides of carbon and nitrogen.