Product Identification

Product Name

5-Hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide

Synonyms

1H-Imidazole-4-carboxamide, 5-hydroxy-1-beta-D-ribofuranosyl-
4-Carbamoyl-1-beta-D-ribofuranosyl-imidazolium-5-olate
5-Hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide
Anhydro-4-carbamoyl-5-hydroxy-1-b-D-ribofuranosyl-imidazolium-hydroxide
Bredinin
HE-69

CAS

50924-49-7

Formula

C9H13N3O6

Molecular Weight

259.22000000000003

RTECS

NI3980000

Merck

12,6306

Beilstein/Gmelin

4151713

Physical and Chemical Properties

Appearance

A natural product, first isolated from the mold Eupenicillium brefeldianum.

Solubility in water

1.4 g/L (25 C)

Density

2.06 g/cm3 (20 C)

pKa/pKb

6.89 (pKa)

Partition Coefficient

-.17

Usage

An immunosuppresive drug.

First Aid Measures

Ingestion

If swallowed, wash out mouth with water provided person is conscious. Call a physician.

Inhalation

If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.

Skin

In case of contact, immediately wash skin with soap and copious amounts of water. Remove contaminated clothing and shoes. Call a physician.

Eyes

In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician.

Handling and Storage

Storage

Store at 2 - 8 C.

Exposure Controls/Personal Protection

Personal Protection

Compatible chemical-resistant gloves. Chemical safety goggles. Protective clothing.

Respirators

Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N99 (US) or type P2 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator.

Exposure Effects

May be harmful by inhalation, ingestion, or skin absorption. Reported to have immunosuppressive effect, causing decrease in number of leucocytes.

Fire Fighting Measures

Fire Fighting

Extinguish with water spray, carbon dioxide, dry chemical powder or appropriate foam. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.

Accidental Release Measures

Small spills/leaks

Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.

Stability and Reactivity

Stability

Stable at normal temperatures and pressures.

Decomposition

Oxides of carbon, oxides of nitrogen.

Hazards Identification

Hazards

Emits toxic fumes under fire conditions.