Product Identification

Product Name

4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide

Synonyms

(2Z,4S,4aR,5S,5aR,6S,12aS)-2-(Amino-hydroxymethylidene)-4-dimethylamino-5,6,10,11,12a-pentahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione
[4S-(4 alpha, 4a alpha, 5 alpha,5a alpha,6 beta,12a alpha)]-4-(dimethylamino)-1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro-3, 5, 6, 10, 12, 12a-hexahydroxy-6-methyl-1, 11-dioxo-2-naphthacenecarboxamide
Adamycin
Berkmycen
Biostat
Dabicycline

CAS

79-57-2

Formula

C22H24N2O9

Molecular Weight

460.44

EINECS

201-212-8

RTECS

QI7875000

RTECS Class

Agricultural Chemical and Pesticide; Drug; Mutagen; Reproductive Effector; Human Data

Merck

12,7111

Beilstein/Gmelin

2714587

Beilstein Reference

4-14-00-02633

Physical and Chemical Properties

Appearance

Pale yellow to tan, crystalline powder.

Solubility in water

0.2 g/L

Melting Point

184.5 - 185.5

Density

1.634 g/cm3 (20 C)

Usage

Inhibition of lethal yellowing in coconut palm trees, bactericide.

Vapor Density

15.9

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.

Handling and Storage

Storage

Store in a cool, dry place. Do not store in direct sunlight. Keep from freezing. Keep container closed when not in use. Store below 40C.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation. Store protected from light.

Hazards Identification

Inhalation

Dust is irritating to the respiratory tract. May cause respiratory tract irritation.

Skin

May cause skin irritation.

Eyes

May cause eye irritation and possible burns.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause an anticoagulant effect in the blood.

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Wear a NIOSH/MSHA or European Standard EN 149 approved full-facepiece airline respirator in the positive pressure mode with emergency escape provisions. A NIOSH/MSHA approved air purifying dust or mist respirator or European Standard EN 149.

Exposure Effects

May cause reproductive and fetal effects. Chronic exposure may cause blood effects.

Fire Fighting Measures

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Substance is noncombustible. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation. Use water spray to reduce vapors or divert vapor cloud drift.

Stability and Reactivity

Incompatibilities

Acidic conditions, strong oxidizing agents.

Stability

Stable under normal temperatures and pressures. Darkens and decomposes on exposure to light.

Decomposition

Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, nitrogen.