Product Identification

Product Name

Dimethyl fumarate

Synonyms

(2E)-2-Butenedioic acid dimethyl ester
Allomaleic acid dimethyl este
Boletic acid dimethyl ester
Dimethyl trans-ethylenedicarboxylate
Methyl fumarate
trans-Butenedioic acid dimethyl ester

CAS

624-49-7

Formula

C6H8O4

Molecular Weight

144.13

EINECS

210-849-0

RTECS

EM6125000

RTECS Class

Primary Irritant

Merck

13,4308

Beilstein/Gmelin

774590

Beilstein Reference

4-02-00-02205

EC Class

harmful, irritant, sensitizing

Physical and Chemical Properties

Appearance

White crystalline powder.

Solubility in water

Soluble

Melting Point

102

Boiling Point

192

Vapor Pressure

0.48 (25 C)

Density

1.37 g/cm3 (20 C)

Partition Coefficient

.62

Heat Of Vaporization

42.9 kJ/mol

Usage

Used to treat psoriasis.

Vapor Density

5

Refractive Index

1.4037 (110.7 C)

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Get medical aid if irritation or symptoms occur.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid if cough or other symptoms appear.

Skin

Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists. Wash clothing before reuse.

Eyes

Get medical aid. Gently lift eyelids and flush continuously with water. Extensive irrigation is required (at least 30 minutes).

Handling and Storage

Storage

Store in a cool, dry place. Keep container closed when not in use. Keep containers tightly closed.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.

Hazards Identification

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea.

Inhalation

Inhalation of dust may cause respiratory tract irritation.

Skin

Causes skin irritation. May be harmful if absorbed through the skin. May cause reddening of the skin.

Eyes

Contact produces irritation, tearing, and burning pain. Causes severe eye irritation and possible injury.

EC Risk Phrase

R 21 36/37/38

EC Safety Phrase

S 26 36/37/39

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear safety glasses and chemical goggles if splashing is possible. Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves and clothing to prevent skin exposure. Clothing: Wear appropriate protective clothing to minimize contact with skin.

Respirators

Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Poison Class

4

Fire Fighting Measures

Flash Point

91

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Use agent most appropriate to extinguish fire. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Disposal Code

3

Incompatibilities

Acids - bases - oxidizing agents - reducing agents.

Stability

Stable under normal temperatures and pressures.

Decomposition

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Transport Information

HS Code

2917 19 90