Product Identification

Product Name

2,4-Dichlorophenyl isocyanate

Synonyms

2,4-Dichloro-1-Isocyanatobenzene
2,4-Dichloro-1-phenyl isocyanate

CAS

2612-57-9

Formula

C7H3Cl2NO

Molecular Weight

188.01

EINECS

220-040-4

Beilstein/Gmelin

2090780

Beilstein Reference

3-12-00-01395

EC Class

very toxic, irritant, sensitizing

Physical and Chemical Properties

Appearance

White to yellow crystalline solid probably with an irritating odor, lachrymator.

Solubility in water

Insoluble

Melting Point

59 - 61

Boiling Point

235

Vapor Pressure

0.05 (25 C)

Partition Coefficient

3.98

Heat Of Vaporization

47.2 kJ/mol

Usage

Monoisocyanates are used as chemical intermediates in the production of drugs, pesticides, amines, ureas and other carbamoyl compounds.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.

Skin

Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Do NOT allow victim to rub or keep eyes closed.

Handling and Storage

Storage

Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture.

Handling

Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Do not allow contact with water. Wash clothing before reuse. Discard contaminated shoes. Keep from contact with moist air and steam.

Hazards Identification

Inhalation

Causes respiratory tract irritation. Exposure produces central nervous system depression. At high concentrations, isocyanates affect mucous membranes of the respiratory tract and may lead to fatal pulmonary edema. Exposure to low and often even unmeasurable isocyanate concentration results in sensitization. Can produce delayed pulmonary edema. In rare instances, exposure may cause sensitization, resulting in inflammation of the mucous membranes and in eczematous eruptions.

Skin

Causes skin irritation. May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material.

Eyes

Causes eye irritation. May cause conjunctivitis, ulceration and turbidity of the cornea.

Ingestion

May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause liver and kidney damage.

Hazards

Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas.

EC Risk Phrase

R 23/25 36/37/38 42

EC Safety Phrase

S 22 26 36/37/39 45

UN (DOT)

2250

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

May cause liver and kidney damage. Effects may be delayed. May cause lung damage. Repeated or prolonged exposure may cause allergic reactions in sensitive individuals. Inhalation of product may aggravate existing chronic repiratory problems such as asthma, emphysema or bronchitis.

Fire Fighting Measures

Flash Point

87

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Extinguishing media: Do NOT get water inside containers. In case of fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Fire Potential

Combustible material: may burn but does not ignite readily.

Accidental Release Measures

Small spills/leaks

Clean up spills immediately, using the appropriate protective equipment. Sweep up, then place into a suitable container for disposal. Provide ventilation. Do not get water inside containers.

Stability and Reactivity

Incompatibilities

Moisture, strong oxidizing agents.

Stability

Stable at room temperature in closed containers under normal storage and handling conditions.

Decomposition

Hydrogen chloride, hydrogen cyanide, nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen, hydrocarbons.

Combustion Products

Fire will produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2250

Hazard Class

6.1

Packing Group

II

HS Code

2929 10 90