Product Identification

Product Name

Methoxsalen

Synonyms

5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone
6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-Lactone
7H-Furo(3,2-g)(1)benzopyran-7-one, 9-methoxy-
8-Methoxy-(furano-3'.2':6.7-coumarin)
9-Methoxyfuro[3,2-g]chromen-7-one
Methoxsalen

CAS

298-81-7

Formula

C12H8O4

Molecular Weight

216.19

EINECS

206-066-9

RTECS

LV1400000

RTECS Class

Tumorigen; Drug; Mutagen; Reproductive Effector

Merck

12,6068

Beilstein/Gmelin

196453

Beilstein Reference

5-19-06-00015

Physical and Chemical Properties

Appearance

Odorless white to cream-colored crystalline solid. Bitter taste followed by tingling sensation.

Solubility in water

Slighty soluble

Melting Point

147

Boiling Point

415

Vapor Pressure

4E-7 (25 C)

Density

1.539 g/cm3

Partition Coefficient

1.31

Heat Of Vaporization

66. kJ/mol

Usage

Suntan accelerator, sunburn protector.

First Aid Measures

Ingestion

Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.

Inhalation

Get medical aid immediately. Remove from exposure to fresh air immediately. If breathing is difficult, give oxygen. Do not use mouth-to-mouth respiration if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device.

Skin

Get medical aid immediately. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.

Eyes

Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately. Do NOT allow victim to rub or keep eyes closed. Extensive irrigation is required (at least 30 minutes).

Handling and Storage

Storage

Corrosives area. Keep containers tightly closed. Store protected from light. Store in a cool, dry area away from incompatible substances.

Handling

Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use only in a well ventilated area. Minimize dust generation and accumulation. Do not get in eyes, on skin, or on clothing. Do not ingest or inhale. Store protected from light. Discard contaminated shoes.

Hazards Identification

Inhalation

Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. May cause systemic effects.

Skin

Causes skin burns. Contact with the skin may cause photosensitivity. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color. May cause erythema and blistering.

Eyes

Causes eye burns. May cause chemical conjunctivitis and corneal damage.

Ingestion

May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. May be harmful if swallowed. May cause systemic effects. May cause nausea, insomnia, nervousness, and depression. May cause liver damage in sufficient quantities.

Hazards

When heated, vapors may form explosive mixtures with air: indoors, outdoors, and sewers explosion hazards.

UN (DOT)

2810

Exposure Controls/Personal Protection

Personal Protection

Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure.

Respirators

A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant a respirator's use.

Exposure Effects

Effects may be delayed.

Poison Class

4

Fire Fighting Measures

Flash Point

205

Fire Fighting

Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

Fire Potential

This material is probably combustible.

Accidental Release Measures

Small spills/leaks

Sweep up, then place into a suitable container for disposal. Avoid generating dusty conditions. Provide ventilation.

Stability and Reactivity

Stability

Stable under normal temperatures and pressures. May decompose when exposed to light.

Incompatibilities

Strong oxidizing agents, direct light.

Decomposition

Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.

Combustion Products

Fire may produce irritating, corrosive and/or toxic gases.

Transport Information

UN Number

2810

Hazard Class

6.1

Packing Group

I; II; III